M. Bhosle, Lalit D. Khillare, Sambhaji T. Dhumal
Mar 1, 2016
Citations
0
Influential Citations
33
Citations
Journal
Chinese Chemical Letters
Abstract
Abstract A convenient synthesis of 6-amino-2 H ,4 H -pyrano[2,3- с ]pyrazole-5-carbonitriles has been accomplished by one pot four-component cyclocondensation of aromatic aldehydes ( 1a-o ) malanonitrile ( 2 ), ethyl acetoacetate ( 3 ), and hydrazine hydrate ( 4 ) in freshly prepared deep eutectic solvent, DES (choline chloride:urea). This protocol has afforded corresponding pyrano[2,3- с ]pyrazoles in shorter reaction time with high yields, and it avoids the use of typical toxic catalysts and solvents.