Leida M. Pretto, Mateus Mittersteiner, Valquiria P. Andrade
Dec 26, 2019
Citations
0
Influential Citations
4
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The synthetic versatility of ethyl 2-(2-ethoxy-3,4-dihydro-2H-pyran-5-yl)-2-oxoacetate for the synthesis of ethyl 2-oxo-2-(1-alkyl/aryl-6-(amino/ethoxy)-1,4,5,6-tetrahydropyridin-3-yl)acetates, from the reaction with primary amines, is presented. The methodology proposed herein is highly chemoselective, and twenty products were obtained in moderate to good yields (up to 87%).