Carlos Fernandes, P. Soares, Alexandra Gaspar
Jul 6, 2016
Citations
0
Influential Citations
5
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The development of new chemical entities represents an important challenge in pharmaceutical industry, being the use of privileged scaffolds for library design and drug discovery a valuable approach. Among the panoply of privileged structures, our research group has focused its attention on the chromone (4 H -benzopyran-4-one) scaffold due to its chemical versatility and ability to bind to multiple targets. With this endeavour we report an expedite two-step procedure for the synthesis of novel 6-aryl/heteroaryl-4-oxo-4 H -chromene-2-carboxylic ethyl ester. The new chromones were synthesized by a C–C Suzuki cross-coupling microwave-assisted reaction, using Pd(OAc) 2 as a catalyst, and a classic Claisen condensation followed by an intramolecular cyclization process.