J. P. Sanchez, J. Rogowski
1987
Citations
0
Influential Citations
8
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
1-Ethyl-6-fluoro-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (8) has been prepared in large quantities by a highly efficient process. It has in turn been degraded to give 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (11). This intermediate has been reacted with piperazine to give the known antibacterial agent, enoxacin (12).