F. Dumont, G. Slegers
Sep 1, 1996
Citations
0
Influential Citations
3
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The synthesis of [ 77 Br] 5,7-dibromo-4-oxo,1,4-dihydroquinoline-2-carboxylic acid is described. The labelling is performed in order to obtain a tracer for SPECT studies of the N-methyl-D-aspartate receptor in human brain. Radiosynthesis was carried out using a non-isotopic nucleophilic halogen exchange, starting from 5-iodo-7-bromo-4-oxo- 1,4-dihydroquinoline-2-carboxylic acid. In order to obtain the best radiochemical yield, several parameters such as reaction temperature, reaction time, amount of precursor and amount of Cu catalyst were studied. Under the best labelling conditions, the radiochemical yield was 85 %. The product was found to be chemically and radiochemically pure as determined by HPLC.