Teng Da-wei
2012
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Journal
Science Technology and Engineering
Abstract
7-benyzl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine was synthesized from 4-imidazole carboxyaldehyde and 2-benzyl aminoethanol in a sequence of reductive amination,chlorization and cyclization in an overall yield of 53%.The effects of solvent and base on cyclization reaction are examined and the optimum reaction conditions are obtained.