A new synthesis of 7H-pyrido[1,2,3-de][1,4]benzoxazine derivatives including an antibacterial agent, ofloxacin.

doi:10.1248/CPB.34.4098

Paper

A new synthesis of 7H-pyrido[1,2,3-de][1,4]benzoxazine derivatives including an antibacterial agent, ofloxacin.

Published Oct 25, 1986 · H. Egawa, T. Miyamoto, J. Matsumoto

Chemical & pharmaceutical bulletin

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24

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0

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Abstract

A new method for the synthesis of 7H-pyrido[1, 2, 3-de][1, 4]benzoxazine derivatives was developed. The method is characterized by the intramolecular cyclization of 1-(1-hydroxyprop-2-yl)-8-fluoro-4-quinolones which are prepared in three or four steps from ethyl 2, 3, 4, 5-tetrafluoro-benzoylacetate. As an application of this method, ofloxacin, an antibacterial agent, was synthesized.

Study Snapshot

This study developed a new method for synthesizing 7H-pyrido[1,2,3-de][1,4]benzoxazine derivatives, including the antibacterial agent ofloxacin, using intramolecular cyclization of 1-(1-hydroxyprop-2-yl)-8

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

A new synthesis of 7H-pyrido[1,2,3-de][1,4]benzoxazine derivatives including an antibacterial agent, ofloxacin.

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References

Pyridonecarboxylic acids as antibacterial agents. V. Synthesis of 1-vinyl-1,4-dihydro-4-oxo-1,8- and 1,6-naphthyridine-3-carboxylic acids.

Pyridonecarboxylic acids show potential as antibacterial agents due to their unique structures and varying antibacterial activities.

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