A new method for the synthesis of 7H-pyrido[1, 2, 3-de][1, 4]benzoxazine derivatives was developed. The method is characterized by the intramolecular cyclization of 1-(1-hydroxyprop-2-yl)-8-fluoro-4-quinolones which are prepared in three or four steps from ethyl 2, 3, 4, 5-tetrafluoro-benzoylacetate. As an application of this method, ofloxacin, an antibacterial agent, was synthesized.

This study developed a new method for synthesizing 7H-pyrido[1,2,3-de][1,4]benzoxazine derivatives, including the antibacterial agent ofloxacin, using intramolecular cyclization of 1-(1-hydroxyprop-2-yl)-8

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A new synthesis of 7H-pyrido[1,2,3-de][1,4]benzoxazine derivatives including an antibacterial agent, ofloxacin.

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