T. Chiba, J. Sakaki, Takumi Takahashi
May 5, 1985
Citations
0
Influential Citations
2
Citations
Journal
Chemistry Letters
Abstract
7-Oxo-4-thia-1-azabicyclo[3.2.0]heptane, a basic skeleton of penicillins, was synthesized for the first time from ethyl propiolate in three steps. The key step was the formation of β-lactam ring of thiazolidine-2-acetic acid by the use of Mukaiyama-Ohno’s method.