Synthesis and antimicobacterial activity of 2-substituted 4-arylamino-6-methylpyrimidines

doi:10.1134/S1070363208100216

Paper

Synthesis and antimicobacterial activity of 2-substituted 4-arylamino-6-methylpyrimidines

Published Dec 3, 2008 · A. V. Erkin, V. Krutikov, E. B. Smirnova

Russian Journal of General Chemistry

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3

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0

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Abstract

Abstract2-Substituted 4-arylamino-6-methylpyrimidines were synthesized by stepwise modification of the structure of 6-methyl-2-thiouracyl through the intermediate 2-(ar)alkylthio-6-methyl-4-chloropyrimidines. Some of the compounds synthesized exhibit expressed antimycobacterial activity.

Study Snapshot

2-Substituted 4-arylamino-6-methylpyrimidines show promising antimycobacterial activity when synthesized by modifying 6-methyl-2-thiouracyl through the intermediate 2-(ar)alkylthio-6-methyl-4-chloropyrimidines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and antimicobacterial activity of 2-substituted 4-arylamino-6-methylpyrimidines

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References

Citations

New pyrimidines and triazolopyrimidines as antiproliferative and antioxidants with cyclooxygenase-1/2 inhibitory potential.

Compound 6f shows promising anticancer and antioxidant properties with COX-2 inhibition, warranting further derivatization and investigation.