Synthesis and antiviral activity of 2-substituted methylthio-5-(4-amino-2-methylpyrimidin-5-yl)-1,3,4-oxadiazole derivatives.

doi:10.1016/j.bmcl.2015.02.069

Paper

Synthesis and antiviral activity of 2-substituted methylthio-5-(4-amino-2-methylpyrimidin-5-yl)-1,3,4-oxadiazole derivatives.

Published May 15, 2015 · Wenneng Wu, Qin Chen, A. Tai

Bioorganic & medicinal chemistry letters

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70

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1

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Abstract

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In Vitro Study

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Study Snapshot

2-substituted methylthio-5-(4-amino-2-methylpyrimidin-5-yl)-1,3,4-oxadiazole derivatives show good antiviral activity against tobacco mosaic virus (TMV), with compound 8i showing better results than Ningnanmycin.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and antiviral activity of 2-substituted methylthio-5-(4-amino-2-methylpyrimidin-5-yl)-1,3,4-oxadiazole derivatives.

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References

Citations

UNVEILING THE POTENTIAL OF OXADIAZOLE TRIAZINE NUCLEOSIDE DERIVATIVE AS AN INHIBITOR OF SARS COV-2: A COMPUTATIONAL BREAKTHROUGH

Oxadiazole triazine nucleoside derivatives 1a and 1m show potential as robust inhibitors of SARS-CoV-2, with excellent binding affinity for main proteases and spike protein.

Synthesis, crystal and molecular structure, DFT and antifungal activity studies of (E)-2-(3-methoxy-4-((6-(trifluoromethyl)pyrimidin-4-yl)oxy)styryl)-5-((2-(trifluoromethyl)benzyl)thio)-1,3,4-oxadiazole

The study synthesized a new compound with antifungal properties, indicating potential applications in agriculture.

N-Heterocycles as Promising Antiviral Agents: A Comprehensive Overview

N-heterocycles show promising antiviral activity and can stimulate the host's immune system, potentially leading to effective antiviral drugs with minimal side effects.

Exploring 2-(benzylthio)-5-(4-nitrophenyl)-1,3,4-oxadiazole as Antiproliferative agent: Synthesis, Single crystal XRD, DFT, Hirshfeld Surface analysis, in vitro Antiproliferative activity and Molecular Docking analysis

2-Btno shows notable anticancer efficacy against Dalton's lymphoma cells, downregulating mitochondrial membrane potential and upregulating reactive oxygen species production.

Discovery of Novel Compounds for Combating Rising Severity of Plant Diseases Caused by Fungi and Viruses

Novel pyrimidine derivatives containing a 1,3,4-oxadiazole thioether fragment show promising antiviral and antifungal activities against various plant diseases.

Synthesis of Some New 1,3,4-Oxadiazole Derivatives and Evaluation of Their Anticancer Activity

New 1,3,4-oxadiazole derivatives show promising anticancer activity, with compounds 4f, 4h, 4i, 4k, and 4l showing excellent cytotoxic profiles on A549 lung cancer cells and remarkable antiproliferative activity on C6 glioma cells.

Design, Synthesis, in Silico and Biological Evaluation of Novel 4‐Aminopyrimidine‐5‐carbonitriles

Novel 4aminopyrimidine-5-carbonitriles show potent inhibitory activity against colorectal and lung cancer cells, with compound 3 h showing the most potent inhibitory activity against human A549 cells.

Synthesis and Antibacterial Evaluation of Pyrazole Integrated Oxadiazole Derivatives

Pyrazole integrated oxadiazole derivatives show potential as antibacterial agents against both gram-positive and gram-negative bacteria.