Synthesis and antimicrobial activity of some new 3–[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2- styrylquinazoline-4(3H)-ones

doi:10.1007/s00044-007-9054-3

Paper

Synthesis and antimicrobial activity of some new 3–[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2- styrylquinazoline-4(3H)-ones

Published Jan 3, 2008 · V. Gupta, S. Kashaw, V. Jatav

Medicinal Chemistry Research

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Abstract

Several 3-[5-(4-substituted)phenyl-1,3,4-oxadiazole-2-yl]-2-styryl quinazoline-4(3H)-one were synthesized and screened for antibacterial activity against Staphylococcus aureus , Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli and antifungal activity against Aspergillus niger and Fusariumoxysporum by the serial dilution technique. Compounds were prepared by reacting corresponding 2-methtyl quinazolinone and 4-subustituted benzaldehydes in glacial acetic acid. Physicochemical and spectral data were consistent with newly synthesized compounds. The prepared compounds were compared with previously synthesized 2-methyl-3-[5-(4-substituted)phenyl-1,3,4-oxadiazole-2-yl]-quinazoline-4(3H)-ones for antimicrobial activity. The present study revealed that styryl moiety at the second position of 4(3H) quinazolinone marginally increased the biological activity and exhibited better antibacterial than antifungal activities.

In Vitro Study

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Study Snapshot

New 3-[5-(4-substituted)phenyl-1,3,4-oxadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones show better antibacterial than antifungal activities against various bacteria and fungi.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and antimicrobial activity of some new 3–[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2- styrylquinazoline-4(3H)-ones

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References

Synthesis of Schiff bases of 2-amino-5-aryl-1,3,4-oxadiazoles and their evaluation for antimicrobial activities.

Schiff bases of 2-amino-5-aryl-1,3,4-oxadiazoles show antibacterial and antifungal properties against various bacteria and fungi.

Synthesis and in vitro study of platelet antiaggregant activity of some 4-quinazolinone derivatives.

New 4-quinazolinone derivatives show antiplatelet activity similar to acetylsalicylic acid, with greater inhibition when aggregation is induced by ADP.

Citations

Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivatives

Quinazoline derivatives show potential as antimicrobial agents against drug-resistant pathogens, offering a promising avenue for developing novel antibiotics.

Ascorbic Acid: An Efficient Organocatalyst for the Synthesis of 2‐Amino‐1,3,4‐oxadiazoles and Thiadiazoles via C−X Bond Formation

Ascorbic acid is an efficient catalyst for the synthesis of 2amino-substituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles without transition metals.

1,3,4- Oxadiazole, A Complete Review on Biological Activities of Newly Synthesized Derivatives

Newly synthesized 1,3,4-oxadiazole derivatives show various biological activities, including anticancer, anti-inflammatory, antimicrobial, analgesic, and anticonvulsant properties.

An Insight into Rational Drug Design: The Development of In-House Azole Compounds with Antimicrobial Activity

Our research group has developed in-house azole compounds with antimicrobial activity, focusing on thiazole, to combat antimicrobial resistance.

Evaluation of the pK's of Quinazoline Derivatives : Usage of Quantum Mechanical Based Descriptors

Quantum mechanical-based computational approaches can accurately predict the pKa of quinazoline derivatives, with the calculated atomic charge on nitrogen atom being the best descriptor for reproducing experimental pKa's.