Synthesis and antimicrobial activity of some new 3-(4-fluorophenyl)-benzo[g]indazoles and 1-pyrazolyl-thiazoles

doi:10.17628/ECB.2014.3.1069-1074

Paper

Synthesis and antimicrobial activity of some new 3-(4-fluorophenyl)-benzo[g]indazoles and 1-pyrazolyl-thiazoles

Published Dec 7, 2014 · B. F. Abdel-Wahab, H. Mohamed, G. Awad

European Chemical Bulletin

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Abstract

A new series of 3-(4-fluorophenyl)-benzo[ g ]indazoles derivatives have been synthesized by simple, high yielding routes. The key step in the construction of the 3-(4-fluorophenyl)-benzo[ g ]indazoles nucleus involves the reaction of α-tetralone with 4-flurobenzaldehyde followed by reaction with hydrazine or thiosemicarbazide. The newly synthesized compounds were evaluated for their antimicrobial activity and compounds 5 , 6b , 12d and 16b demonstrated inhibitory effects on the growth of a wide range of microbes.

Study Snapshot

New 3-(4-fluorophenyl)-benzo[g]indazoles derivatives show antimicrobial activity against a wide range of microbes, making them promising candidates for antimicrobial coatings.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and antimicrobial activity of some new 3-(4-fluorophenyl)-benzo[g]indazoles and 1-pyrazolyl-thiazoles

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References

Citations

Synthesis and Biological Evaluation of Novel 1,4-Disubstituted 1,2,3-Triazoles and Bis 1,2,3-Triazoles as Anti-Bacterial Agents

Novel 1,4-disubstituted 1,2,3-triazoles show high inhibitory effects against various bacterial strains, with compounds 3g and 3b showing the most activity against various gram-positive and gram-negative bacteria.