Synthesis and anticonvulsant activity of some 4-nitro-N-phenylbenzamides.

doi:10.1016/0223-5234(96)88254-7

Paper

DOI: 10.1016/0223-5234(96)88254-7

Synthesis and anticonvulsant activity of some 4-nitro-N-phenylbenzamides.

Published 1995 · V. Bailleux, L. Vallée, J. Nuyts

European journal of medicinal chemistry

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Four 4-nitro-N-phenylbenzamides show promising anticonvulsant properties, with N-(2-chloro-6-methylphenyl)-4-nitrobenzamide being three times more active than phenytoin and 4-amino-N-(2,6-dimethylphenyl

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1016/s0026-895x(25)09256-9

[3H]Phenytoin identifies a novel anticonvulsant-binding domain on voltage-dependent sodium channels.

Phenytoin interacts with voltage-dependent sodium channels at therapeutic concentrations, supporting its therapeutic effects as a selective inhibitor of voltage-dependent sodium flux.

1992·31citations·J. Francis et al.·Molecular pharmacology

Molecular pharmacology

DOI:

Frequency and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs.

Phenytoin, carbamazepine, lidocaine, and verapamil effectively block type IIA Na+ channels in rat brain, potentially contributing to their anticonvulsant action.

1991·228citations·David S. Ragsdale et al.·Molecular pharmacology

Molecular pharmacology

DOI: 10.1111/j.1528-1157.1989.tb05300.x

Phenytoin and Carbamazepine: Potential‐ and Frequency‐Dependent Block of Na Currents in Mammalian Myelinated Nerve Fibers

Phenytoin and carbamazepine are both selective blockers of Na channels in mammalian myelinated nerve fibers, with phenytoin having a stronger slowing effect and frequency-dependent block.

1989·147citations·J. Schwarz et al.·Epilepsia

Epilepsia

DOI: 10.1111/J.1528-1157.1988.TB04420.X

Comparative anticonvulsant activity and neurotoxicity of 4-amino-N-(2,6-dimethylphenyl)benzamide and prototype antiepileptic drugs in mice and rats.

ADD 75073 is a potent anticonvulsant with a similar pharmacologic profile to phenytoin, but ineffective in other seizure models.

1988·39citations·Clark Cr·Epilepsia

Epilepsia

DOI: 10.1021/JM00390A016

Synthesis and anticonvulsant activity of analogues of 4-amino-N-(1-phenylethyl)benzamide.

Analogues of 4-amino-N-(1-phenylethyl)benzamide show potential anticonvulsant activity, but modifying their structure can decrease their effectiveness.

1987·22citations·C. Clark et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

Citations

DOI: 10.1002/ardp.201700265

Biological evaluation and pharmacophore modeling of some benzoxazoles and their possible metabolites

Benzoxazole derivatives show strong genotoxic effects against cancerous cells, making them potential anticancer candidates.

2018·14citations·F. Zilifdar et al.·Archiv der Pharmazie

Archiv der Pharmazie

DOI: 10.4172/2329-6798.1000194

Pharmacological Potential of Benzamide Analogues and their Uses in Medicinal Chemistry

Benzamide analogues possess various pharmacological activities, making them a promising target for developing new and more effective pharmaceuticals.

2016·36citations·M. Asif·Modern Chemistry & Applications

Modern Chemistry & Applications

DOI: 10.1016/j.seizure.2014.11.006

Can pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans?

The pentylenetetrazole model accurately predicts human exposures more accurately than the maximal electroshock model, with both species being useful tools in early drug discovery.

2015·47citations·E. Yuen et al.·Seizure

Seizure

DOI: 10.1055/s-0031-1296331

Synthesis and anticonvulsant activity of some alkanamide derivatives

The 1, 2, 4-triazole ring in alkanamide derivatives leads to superior anticonvulsant activity, with the most active compound being 2-(lH-l, 2, 4-triazole-l-yl)-N-(2, 6-dimethylphenyl) acetamide.

2010·4citations·Ayse H. Tarikogullari et al.·Arzneimittelforschung

Arzneimittelforschung

DOI: 10.1016/J.FARMAC.2003.07.011

Synthesis and anticonvulsant activity of some omega-(1H-imidazol-1-yl)-N-phenylacetamide and propionamide derivatives.

Omega-(1H-imidazol-1-yl)-N-phenylacetamide and propionamide derivatives with 2-isopropyl and 2,6-dimethyl substituents show the most anticonvulsant activity against maximal electroshock test.

2004·23citations·Zeynep Soyer et al.·Farmaco

Farmaco

DOI: 10.1016/S0968-0896(98)00057-1

Synthesis and anticonvulsant properties of triazolo- and imidazopyridazinyl carboxamides and carboxylic acids.

Analogues with imidazole rings substituted with amide groups show greater anticonvulsant activity than those with carboxylic acid functions.

1998·31citations·Stéphane Moreau et al.·Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

DOI:

MAKALE SYNTHESIS , IN SILICO AND IN VITRO ANTIPROLIFERATIVE STUDIES OF SOME NOVEL BENZAMIDO SUBSTITUTED IMIDAZO [ 1 , 2-b ] PYRIDAZIN-2-ONES

Novel benzamido substituted imidazo[1,2-b]pyridazin-2-ones show promising anti-proliferative activity against human cancer cell lines A375 and Colo-205, with potential druggable candidates and no toxicity or teratogenecity.

2017·0citations·M. Sumakanth et al.

DOI: 10.1016/S0753-3322(97)86911-9

Anticonvulsant and neurotoxicological properties of 4-amino-N-(2-ethylphenyl)benzamide, a potent ameltolide analogue.

4-AEPB shows potent anticonvulsant properties and neurotoxicity, making it a promising candidate for future pharmacological development.

1997·17citations·O. Diouf et al.·Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie