.. R.V.Sidhaye, .. A.E.Dhanawade, .. K.Manasa
Feb 15, 2011
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Abstract
Pyridine 3-carboxillic acid 1 on treatment with phosphorous pentachloride and anhydrous carbon tetrachloride followed by reaction with hydrazine hydrate gave nicotinohydrazide 2. And compound 2 on further reaction with acetyl acetone, ethyl acetoacetate, ethylcyanoacetate and different substituted aromatic acids yielded the corresponding (3,5-dimethyl-1H-pyrazol-1-yl)(pyridine-3-yl)methanone 3, 3-methyl-1-nicotinoyl-1H-pyrazol5(4H)-one 4, 3-amino-1-nicotinoyl-1H-pyrazol-5(4H)-one 5 and 3-(5-substituted-1,3,4 oxadiazole) pyridine 6ad, respectively. All the synthesized compounds have been screened for their antimycobacterial activity.