Synthesis and anticonvulsant activity of some new bishydrazones derived from 3,4-dipropyloxythiophene.

doi:10.1016/j.ejmech.2009.02.009

Paper

DOI: 10.1016/j.ejmech.2009.02.009

Synthesis and anticonvulsant activity of some new bishydrazones derived from 3,4-dipropyloxythiophene.

Published Sep 1, 2009 · Ravi Kulandasamy, A. Adhikari, J. Stables

European journal of medicinal chemistry

Q2 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

New bishydrazones derived from 3,4-dipropyloxythiophene show promising anticonvulsant activity with less neurotoxicity compared to existing compounds.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1016/J.EJMECH.2007.08.002

Convenient access to 1,3,4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1,3-dipolar cycloaddition of sydnones with acetylenic ketones and their antimicrobial evaluation.

The synthesized 1,3,4-trisubstituted pyrazoles show promising antibacterial and antifungal activities against various microorganisms.

2008·132citations·N. S. Rai et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1016/J.EJMECH.2007.01.007

Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.

New tetrasubstituted thiophenes show promising anti-inflammatory and analgesic properties, with the best compounds showing significant protection in carrageenin-induced rat hind paw oedema models.

2007·66citations·K. Molvi et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1016/J.EJMECH.2006.11.007

Synthesis of some new bioactive 3-amino-2-mercapto-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one derivatives.

New bioactive compounds synthesized from 3-amino-2-mercapto-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one show promising anti-inflammatory, CNS depressant, and antimicrobial activities

2007·74citations·B. V. Ashalatha et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1016/J.EJMECH.2006.08.010

Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore.

Most of the synthesized compounds showed effective anticonvulsant properties in the scSTY and ipPIC models, but ineffective in the MES test.

2007·215citations·J. V. Ragavendran et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1016/J.BMC.2005.12.041

2,4-Dimethoxyphenylsemicarbazones with anticonvulsant activity against three animal models of seizures: synthesis and pharmacological evaluation.

N1-(2,4-dimethoxyphenyl)-N4-(propan-2-one)semicarbazone (17) shows the most active anticonvulsant activity in mice, with no neurotoxicity, and is comparable to clobazam in elevating GABA levels.

2006·72citations·R. Thirumurugan et al.·Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

Citations

DOI: 10.1080/10406638.2022.2138922

Synthesis and in Silico Antiviral Activity of Novel Bioactive Thiobarbituric Acid Based Hydrazones and Pyrazoles against SARS-CoV-2 Main Protease (Mpro)

Novel thiobarbituric acid-based hydrazones and pyrazoles show potential inhibitory activity against SARS-CoV-2 main protease, with pyrazolinone 19 showing the lowest docking score.

2022·12citations·Tariq Z. Abolibda et al.·Polycyclic Aromatic Compounds

Polycyclic Aromatic Compounds

DOI: 10.1016/j.jorganchem.2022.122411

Recyclable gold(I)-catalyzed hydrohydrazidation of terminal alkynes towards keto-N-acylhydrazones

Gold(I)-catalyzed hydrohydrazidation of terminal alkynes in chlorobenzene produces a wide variety of substituted keto-N-acylhydrazones with high yields and is easily recyclable up to eight times without loss of catalytic efficiency.

2022·0citations·Siqi Liu et al.·Journal of Organometallic Chemistry

Journal of Organometallic Chemistry

DOI: 10.1007/s13738-020-01987-y

Synthesis, cytotoxicity and in vitro antibacterial screening of novel hydrazones bearing thienopyridine moiety as potent COX-2 inhibitors

Novel hydrazones bearing thienopyridine moiety show strong antibacterial activities and promising inhibitory activities against COX-2 enzyme, with potential as new antibacterial drugs.

2020·27citations·S. Sanad et al.·Journal of the Iranian Chemical Society

Journal of the Iranian Chemical Society

DOI: 10.1039/d0dt00210k

Mitochondria-localizing dicarbohydrazide Ln complexes and their mechanism of in vitro anticancer activity.

Complexes 1 and 3 show promising anticancer activity against SK-OV-3 and A549 tumor cells, with potential for future clinical trials.

2020·16citations·Ting Meng et al.·Dalton transactions

Dalton transactions

DOI: 10.1021/acs.jafc.8b06175

Discovery of Pimprinine Alkaloids as Novel Agents against a Plant Virus.

Pimprinine alkaloids show promising antiviral activities against tobacco mosaic virus, with potential for future development as novel antiviral agents.

2019·57citations·B. Liu et al.·Journal of agricultural and food chemistry

Journal of agricultural and food chemistry

DOI: 10.1021/acs.orglett.8b02019

Gold-Catalyzed Hydrohydrazidation of Terminal Alkynes.

Gold-catalyzed hydrohydrazidation of alkynes with various hydrazides leads to a wide range of substituted keto-N-acylhydrazones in excellent to good yields (99-66%) under mild conditions and high functional group tolerance.

2018·18citations·Dmitry P. Zimin et al.·Organic letters

Organic letters

DOI: 10.1016/j.jtumed.2017.10.007

Biological investigation of novel metal complexes of 2-amino-4-substituted phenylthiazole Schiff bases

Novel metal complexes of 2-amino-4-substituted phenylthiazole Schiff bases show significant antibacterial activities against drug-resistant bacterial strains and potent radical-scavenging properties.

2017·11citations·J. Sahoo et al.·Journal of Taibah University Medical Sciences

Journal of Taibah University Medical Sciences

DOI: 10.1007/s00044-017-2114-4

Design, synthesis, anticonvulsant activity, and pharmacophore study of new 1,5-diaryl-1H-1,2,4-triazole-3-carboxamide derivatives

New 1,5-diaryl-1H-1,2,4-triazole-3-carboxamide derivatives show promising anticonvulsant activity and mild neurotoxicity, with compound 4f showing excellent activity against electroshock.

2017·12citations·Abdelfattah H. Abuelhassan et al.·Medicinal Chemistry Research

Medicinal Chemistry Research

DOI: 10.1039/C7GC00730B

Stereoselective, solvent free, highly efficient synthesis of aldo- and keto-N-acylhydrazones applying grindstone chemistry

This study presents a simple, solvent-free method for the efficient synthesis of aldo- and keto-N-acylhydrazones, resulting in stereoselective products and avoiding tedious work-up and harmful solvents.

2017·10citations·J. Filho et al.·Green Chemistry

Green Chemistry