V. A. Bodarenko, K. A. Zaitseva, E. E. Mikhlina
Nov 1, 1978
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Influential Citations
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Journal
Pharmaceutical Chemistry Journal
Abstract
We decided to synthesize analogous N-acyl derivatives of 3-aminoquinuclidine and screen them for antlarrhythmic activity. 3-(Acylamino)quinuclidines are both analogs of 3-benzoyloxyquinuclidine and ethylenediamine derivatives in which one of the nitrogen atoms is incorporated in the qulnuclidine ring. N,N'-Disubstituted ethylenediamines and their alkanoyl derivatives are known to have antiarrhythmic activity [4, 5].