T. Smirnova, M. Y. Gavrilov, L. P. Drovosekova
Mar 1, 1997
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Journal
Pharmaceutical Chemistry Journal
Abstract
As was demonstrated previously, 2-arylamino-5,6,7,8tetrahydroquinoline-3-carboxylic acid amides exhibit antiinflammatory and analgesic activity [1]. The same types of activity were reported for substituted amides of 2-anilinocinchoninic acid [2]. Derivatives of 5,6,7,8-tetrahydroquinoline-4-carboxylic acid, which are structurally analogous to these compounds, have not been characterized. Some data were only reported for 2-oxo-l,2,5,6,7,8-haxahydroquinoline-4-carboxylic acid (I) and a methyl ester of 2-chloro5,6,7,8-tetrahydroquinoline-4-carboxylic acid, which were used as the initial compounds in the synthesis of 5,6,7,8-tetrahydroquinoline-4-carboxylic acid hydrazides expected to possess antituberculous activity [3]. The purpose of this work was to search for new antiinflammatory, analgesic, and anticonvulsive agents among a series of isopropylamides of 2-arylamino-5,6,7,8-tetrahydroquinoline-4-carboxylic acids.