Synthesis and antibacterial activity of novel 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide derivatives

doi:10.1186/s13065-015-0121-4

Paper

Synthesis and antibacterial activity of novel 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide derivatives

Published Sep 24, 2015 · S. Kethireddy, L. Eppakayala, T. C. Maringanti

Chemistry Central Journal

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13

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Abstract

BackgroundThe intensely increasing multi-drug resistant microbial infections have encouraged the search for new antimicrobial agents. Hydrazone derivatives are known to exhibit a wide variety of biological activities including anti-microbial. In heterocyclic moiety, imidazo[1,2-a]pyrimidines are the subject of immense interest for their antimicrobial activity and also for their analgesic, antipyretic and anti-inflammatory properties.ResultsCondensation of 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide 7 with aromatic aldehydes a–k in ethanol at reflux led to the generation of hydrazone derivatives 8a–k in 80–92% yield. The synthesis of carbohydrazide 7 was accomplished in six steps from commercially available 2-amino pyrimidine. The structures of the synthesized compounds were confirmed by 1H, 13C NMR, Mass and IR spectral data. All the synthesized hydrazone derivatives 8a–k were tested in vitro for their antibacterial activity. Compounds 8d, 8e and 8f exhibited excellent antibacterial activity with zone of inhibition 30–33 mm against E. coli (Gram negative bacteria) and S. aureus (Gram positive bacteria). These compounds also exhibited excellent antibacterial activity with zone of inhibition 22–25 mm against P. aeruginosa (Gram negative bacteria) and S. pyogenes (Gram positive bacteria).ConclusionSynthesized and recorded antibacterial activity of some new 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine-hydrazone derivatives.Graphical abstract:Synthesis of 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide derivatives

In Vitro Study

Study Snapshot

New 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-hydrazone derivatives show excellent antibacterial activity against E. coli, S. aureus, and P. aeruginosa.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and antibacterial activity of novel 5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carbohydrazide derivatives

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Citations

Synthesis and antimycotic activity of new derivatives of imidazo[1,2-a]pyrimidines

New imidazo[1,2-a]pyrimidine derivatives show potential antifungal activity against Candida albicans, with promising results compared to voriconazole.

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