Paper
Synthesis and antioxidant activity of novel Mannich base of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan.
Published Nov 1, 2013 · Liang Ma, Yu Xiao, Cong Li
Bioorganic & medicinal chemistry
Q2 SJR score
54
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Novel Mannich base of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan compounds show significant antioxidant activity, comparable to BHT and Trolox.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Mannich bases of scutellarein as thrombin-inhibitors: design, synthesis, biological activity and solubility.
Morphinyl aminomethylene substituted derivative ( 3d) shows stronger anticoagulant activity, better water solubility, and good antioxidant activity compared to scutellarein ( 2), warranting further development for ischemic cerebrovascular disease treatment.
2012·46citations·Nianguang Li et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Synthesis and antioxidant activity of 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives.
Newly synthesized 1,3,4-oxadiazole tagged thieno[2,3-d]pyrimidine derivatives show significant antioxidant activity due to electron-donating substituents on both sides of the thienopyrimidine ring.
2012·122citations·Y. Kotaiah et al.·European journal of medicinal chemistry
European journal of medicinal chemistry
Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents.
Compound 5c, a novel series of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines, shows potential as a potent anti-inflammatory and antioxidant agent.
2012·93citations·B. Bandgar et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Synthesis and Evaluation of a Series of 2-Substituted-5-Thiopropylpiperazine (Piperidine)-1,3,4-Oxadiazoles Derivatives as Atypical Antipsychotics
Compound 22 shows atypical antipsychotic activity without extrapyramidal symptoms, making it a promising candidate for developing a novel class of drug for schizophrenia treatment.
2012·15citations·Yin Chen et al.·PLoS ONE
PLoS ONE
ANTIOXIDANT POTENTIAL AND DNA DAMAGE PROTECTING ACTIVITY OF AQUEOUS EXTRACT FROM ARMILLARIA MELLEA
Aqueous extract from Armillaria mellea mushroom shows notable antioxidant properties, inhibiting lipid peroxidation and protecting DNA from oxidative stress-related diseases.
2012·15citations·L. Gao et al.·Journal of Food Biochemistry
Journal of Food Biochemistry
Citations
Design, synthesis, crystal structure, fungicidal activity, and mechanism of action of novel thiazole-based hydrazide derivatives containing the 4-aminoquinazoline moiety.
Novel thiazole-based hydrazide derivatives with the 4-aminoquinazoline moiety show significant antifungal activity against phytopathogenic fungi, with compound A19 showing the highest effectiveness against Rhizoctonia solani.
2025·0citations·Mingyan Yi et al.·Bioorganic chemistry
Bioorganic chemistry
1,3,4-oxadiazole derivatives: synthesis, characterization, antifungal activity, DNA binding investigations, TD-DFT calculations, and molecular modelling.
1,3,4-oxadiazole derivatives show potent antifungal activity against Candida species, with potential for use in anti-aging treatments and anti-aging research.
2023·1citation·Rabiya Mehandi et al.·Journal of biomolecular structure & dynamics
Journal of biomolecular structure & dynamics
A combined crystallographic and theoretical investigation of noncovalent interactions in 1,3,4-oxadiazole-2-thione-N-Mannich derivatives: in vitro bioactivity and molecular docking
1,3,4-oxadiazole-2-thione-N-Mannich derivatives show antimicrobial activity against Gram-positive bacteria and anti-proliferative activity against hepatocellular carcinoma and mammary gland breast cancer cell lines.
2023·3citations·L. Al-Wahaibi et al.·RSC Advances
RSC Advances
Novel quinazolin-4(3H)-one bionic-alkaloids bearing an 1,3,4-oxadiazole fragment as potential fungicides inhibiting Botrytis cinerea: Design, synthesis and bioactive-guided structural optimization
The novel quinazolin-4(3H)-one bionic-alkaloids bearing an 1,3,4-oxadiazole fragment show potential as effective fungicides for controlling Botrytis cinerea, with a 69.3% in vivo preventative efficacy compared to bos
2023·2citations·Xiaobin Wang et al.·Arabian Journal of Chemistry
Arabian Journal of Chemistry
Synthesis, Computational Studies, Antioxidant and Anti-Inflammatory Bio-Evaluation of 2,5-Disubstituted-1,3,4-Oxadiazole Derivatives
Ox-6a-f, a 1,3,4-oxadiazole derivative, shows promising antioxidant and anti-inflammatory properties, with 80.23% radical scavenging potential and a stable complex with COX-2.
2023·10citations·Sibghat Mansoor Rana et al.·Pharmaceuticals
Pharmaceuticals
Recent advances in biological applications of mannich bases — An overview
Mannich bases have powerful anti-inflammatory, anticancer, and other properties, making them potential therapeutic agents for various diseases and mental health issues.
2023·2citations·Senthil Kumar Raju et al.·International Journal of Pharmaceutical Chemistry and Analysis
International Journal of Pharmaceutical Chemistry and Analysis
Interactions of N-Mannich Bases of Pyrrolo[3,4-c]pyrrole with Artificial Models of Cell Membranes and Plasma Proteins, Evaluation of Anti-Inflammatory and Antioxidant Activity
Pyrrolo[3,4-c]pyrrole derivatives show promising anti-inflammatory and antioxidant activity with potential good membrane permeability for oral administration.
2023·0citations·Łukasz Szczukowski et al.·Membranes
Membranes
Microwave-assisted synthesis, molecular docking studies of 1,2,3-triazole-based carbazole derivatives as antimicrobial, antioxidant and anticancer agents
The synthesized 1,2,3-triazole-based carbazole derivatives exhibit good antimicrobial, antioxidant, and anticancer activities, with molecular docking studies indicating their best fit into target receptors.
2022·6citations·D. Ashok et al.·RSC Advances
RSC Advances