K. Ravindra, H. Vagdevi, V. Vaidya
Feb 17, 2008
Citations
0
Influential Citations
12
Citations
Journal
Arkivoc
Abstract
Ethyl 3-aminonaphtho(2,1-b)furan-2-carboxylate 1 was converted into 3-amino-2- mercaptonaphthofuro(3,2-d)pyrimidin-4(3H)-one 4 by reacting it with carbon disulphide followed by methylation and condensation with hydrazine hydrate. The compound 4 on treatment with aryl isothiocyanates produced 2-arylaminoanilinonaphtho(2,1-b)furo-5H-(3,2- d)(1,3,4)thiadiazolo(3,2-a)pyrimidin-5-ones 5(a-h). The title compounds 6(a-h) were obtained also by reacting 4 with aromatic acids in presence of phosphorus oxychloride. The structures of the newly synthesized compounds were confirmed by IR, 1 H NMR, 13 C NMR and mass spectral studies and elemental analysis. All the synthesized compounds have been screened for antimicrobial activity.