Synthesis and antibacterial activity of new N-substituted 7-amino-4-methyl-2H-chromen-2-ones

doi:10.1007/s11164-016-2510-2

Paper

Synthesis and antibacterial activity of new N-substituted 7-amino-4-methyl-2H-chromen-2-ones

Published Mar 25, 2016 · K. Anusevičius, I. Jonuškienė, B. Sapijanskaitė

Research on Chemical Intermediates

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6

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1

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Abstract

N-Substituted 7-amino-4-methyl-2H-chromen-2-ones containing one or two functionalized azole or azine moieties were synthesized. The structures of all synthesized compounds were confirmed by IR, ^1H NMR, and ^13C NMR spectroscopy. Some of the synthesized compounds exhibited weak antibacterial activity against Rhizobium radiobacter, Escherichia coli, and Xanthomonas campestris.

Study Snapshot

N-substituted 7-amino-4-methyl-2H-chromen-2-ones show weak antibacterial activity against Rhizobium radiobacter, Escherichia coli, and Xanthomonas campestris.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and antibacterial activity of new N-substituted 7-amino-4-methyl-2H-chromen-2-ones

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References

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Citations

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Azole-based antibacterial agents show potential in treating various infections and have shown anticancer and anti-inflammatory properties, making them a crucial drug discovery target.

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This study demonstrates the synthesis and structure of new N -alkyl(hetaryl)idenecarbohydrazides with aromatic aldehydes, acetone, and acetophenone, offering potential applications in organic synthesis and catalysis.

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