Paper
Synthesis and biological activity of new phthalimides as potential anti-inflammatory agents.
Published Jul 1, 2017 · Duc-Hiep Bach, Jian-Yu Liu, Won Kyung Kim
Bioorganic & medicinal chemistry
Q2 SJR score
41
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Novel phthalimides show potential as anti-inflammatory agents by suppressing nitric oxide production and suppressing pro-inflammatory cytokines.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways
Schizandrin A shows anti-inflammatory and neuroprotective effects by alleviating microglia-mediated neuroinflammation injury through inhibiting TRAF6-IKK-NF-B and Jak2-Stat3 signaling pathways.
2016·84citations·Fang-jiao Song et al.·PLoS ONE
PLoS ONE
Salternamide A Suppresses Hypoxia-Induced Accumulation of HIF-1α and Induces Apoptosis in Human Colorectal Cancer Cells
Salternamide A effectively inhibits hypoxia-induced HIF-1 accumulation and induces apoptosis in human colorectal cancer cells, making it a potential anticancer agent.
2015·32citations·Duc-Hiep Bach et al.·Marine Drugs
Marine Drugs
N(6)-(2-Hydroxyethyl)adenosine in the Medicinal Mushroom Cordyceps cicadae Attenuates Lipopolysaccharide-Stimulated Pro-inflammatory Responses by Suppressing TLR4-Mediated NF-κB Signaling Pathways.
The medicinal mushroom Cordyceps cicadae, containing N6-(2-Hydroxyethyl)adenosine (HEA), effectively reduces inflammation by suppressing TLR4-mediated NF-B signaling pathways.
2015·69citations·Meng-Ying Lu et al.·Journal of natural products
Journal of natural products
Compounds from Geijera parviflora with prostaglandin E2 inhibitory activity may explain its traditional use for pain relief.
Australian Aboriginal people used Geijera parviflora leaves for pain relief due to the presence of compounds with anti-inflammatory activity, particularly flindersine and a derivative.
2015·13citations·L. Banbury et al.·Journal of ethnopharmacology
Journal of ethnopharmacology
The Extract of Ziziphus jujuba Fruit (Jujube) Induces Expression of Erythropoietin Via Hypoxia-Inducible Factor-1α in Cultured Hep3B Cells
Jujube fruit extract stimulates erythropoietin expression in liver cells, enhancing hematopoietic function and potentially benefiting liver health.
2014·29citations·Jianping Chen et al.·Planta Medica
Planta Medica
Citations
Phthalimides as anti-inflammatory agents.
Phthalimide derivatives show promising anti-inflammatory properties, offering hundreds of promising drug candidates with exceptional therapeutic potential.
2024·1citation·H. M. Heras Martinez et al.·Future medicinal chemistry
Future medicinal chemistry
Unveiling the anti-cancer potentiality of phthalimide-based Analogues targeting tubulin polymerization in MCF-7 cancerous Cells: Rational design, chemical Synthesis, and Biological-coupled Computational investigation.
Compound 6c shows potential as an anti-breast cancer agent by inhibiting tubulin polymerization and inducing apoptosis in MCF-7 cells.
2024·1citation·A. Aljuhani et al.·Bioorganic chemistry
Bioorganic chemistry
Structure-Activity Relationship of 5-butyl-4,6-dimethyl-2-{[4-(o-fluorophenyl)-1-piperazinyl]-2-oxoethyl}-pyrrolo[3,4-c]pyrrole-1,3(2H,5H)-dione: an experimental and theoretical study
The synthesized compound exhibits higher anti-inflammatory activity than Meloxicam, with stronger binding affinity for COX-1 and COX-2 enzymes.
2024·0citations·A. Redzicka et al.·Journal of Molecular Structure
Journal of Molecular Structure
Phthalimides: developments in synthesis and functionalization
Phthalimides are crucial building blocks in organic transformations, and synthetic methods have advanced over the past two decades to prepare functionalized phthalimides for various applications.
2024·0citations·Fatemeh Doraghi et al.·RSC Advances
RSC Advances
An Efficient Synthesis of 1-(1,3-Dioxoisoindolin-2-yl)-3-aryl Urea Analogs as Anticancer and Antioxidant Agents: An Insight into Experimental and In Silico Studies
The efficient synthesis of 1-(1,3-dioxoisoindolin-2-yl)-3-aryl urea analogs (7a-f) demonstrates potential anticancer and antioxidant properties, with compounds 7c showing better anticancer activity than thalidomide and melanom
2023·0citations·O. Afzal et al.·Molecules
Molecules
Insights into the advances in therapeutic drugs for neuroinflammation-related diseases.
Therapeutic advances in neuroinflammation-related diseases show promise, but no approved medications currently prevent or cure neuroinflammation.
2023·1citation·Bozhi Luo·The International journal of neuroscience
The International journal of neuroscience