J. Oiry, J. Y. Pue, J. Laval
1995
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
European Journal of Medicinal Chemistry
Abstract
Summary N -(2-Acetylthioethyl)-1,3-propanediamine ( 13a , as its 2HBr salt, or 13b , as its 2CF 3 CO 2 H salt) and N,N′ -bis(2-acetylthioethyl)-1,3-propanediamine ( 16 , as its 2CF 3 CO 3 H salt) have been prepared and evaluated as potential radioprotectors in mice. Their toxicity and radioprotective activity (survival rate) have been determined and compared with that of WR-2721. Intermediate N -(2-acetylthioethyl)- N,N′ -bis(Z or Boc)-1,3-propanediamines were prepared in two ways from the corresponding alcohols. The most convenient method (the Mitsunobu procedure) was used to obtain the N,N′ -bis(2-acetylthioethylated) derivative from the corresponding diol. Surprisingly, none of these compounds possesses radioprotective activity.