C. Merser, Pierre Sinaÿ, Arlette Adam
Oct 27, 1975
Citations
2
Influential Citations
184
Citations
Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
Abstract 2-Acetamido-2-deoxy-3-O-(D-2-propionyl-L-alanine)-D-glucopyranose ( 5 ) and 2-acetamido-2-deoxy-3-O-(D-2-propionyl-L-alanyl-D-isoglutamine)-D-glucopyranose ( 10 ) have been synthesized by condensation of benzyl 2-acetamido-4,6-O-benzylidene-3-O-(D-1-carboxyethyl)-2-deoxy-β-D-glucopyranoside ( 1 ) respectively with the L-alanine derivative 2 and the dipeptide 7 , followed by debenzylidenation and hydrogenolysis. Compound 10 is adjuvant active, whereas 5 is inactive, so that 10 is the smallest adjuvant active structure for the time being.