Wu Qiu-ye
2007
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Alosetron hydrochloride was synthesized from sodium methyl 2,4-dioxo-3-piperidinecarboxylate by hydrolytic decarboxylation condensation with N-methylphenylhydrazine,cyclization and condensation with 4-hydroxy-methyl-5-methylimidazole with an overall yield of 40%.