Zhuang Zhihong, Li Rongdong
2001
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Alosetron hydrochloride was synthesized from β alanine via esterification, amidation, cyclization, hydrolysis, condensation, cyclization, condensation and salt formation in 15.6% overall yield. The work up treatments of intermediats 8 and 11 were improved.