H. Khalid, Aziz‐ur‐Rehman, M. Abbasi
Sep 1, 2016
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Influential Citations
23
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Journal
Journal of Saudi Chemical Society
Abstract
Abstract 1,3,4-Oxadiazole bearing compounds are one of the most attractive class for researchers due to their biological activities. In the undertaken research, a number of N -substituted derivatives of 2-(5-(1-(phenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazol-2-ylthio)acetamide ( 6a–n ) were synthesized through a series of steps. The reaction of benzenesulfonyl chloride with ethyl isonipecotate yielded ethyl 1-(phenylsulfonyl)piperidin-4-carboxylate ( 1 ), which was further converted into 1-(phenylsulfonyl)piperidin-4-carbohydrazide (2) and 5-(1-(phenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazol-2-thiol (3) respectively. The target compounds 6a–n were synthesized by the reaction of compound 3 with different N -aralkyl/aryl substituted 2-bromoacetamides ( 5a–n ) in the presence of a weak base and polar aprotic solvent. The structures of the synthesized compounds were elucidated through 1 H-NMR, IR and mass spectral data. The synthesized compounds were screened against Gram-negative and Gram-positive bacteria and exhibited moderate to talented activity.