Johannes A. Burkhard, Carine M Guérot, H. Knust
Mar 31, 2010
Citations
0
Influential Citations
73
Citations
Quality indicators
Journal
Organic letters
Abstract
Straightforward access toward previously unreported substituted, heterocyclic spiro[3.3]heptanes is disclosed. These spirocyclic systems may be considered as alternatives to 1,3-heteroatom-substituted cyclohexanes, which are otherwise insufficiently stable to allow their use in drug discovery. Conformational details are discussed on the basis of X-ray crystallographic structures.