Synthesis and conformational analysis of constrained ethylene-bridged bis(hydroxylamino-1,3,5-triazine) compounds as tetradentate ligands; structure of rigid dinuclear Ti(IV) complex.

doi:10.1021/jo800966s

Paper

Synthesis and conformational analysis of constrained ethylene-bridged bis(hydroxylamino-1,3,5-triazine) compounds as tetradentate ligands; structure of rigid dinuclear Ti(IV) complex.

Published Jun 24, 2008 · Tal Hermon, Edit Y. Tshuva

The Journal of organic chemistry

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Abstract

Ethylene-bridged bis(hydroxylamino-1,3,5-triazine) compounds, that may serve as tetradentate ligands, were synthesized in three steps from 2,4,6-trichloro-1,3,5-triazine. These compounds demonstrate different rotation restrictions around the C(Ar)-N bonds due to their distinctive electronic structure as apparent from their resonative contributors. A dinuclear complex Ti 2(mu-L)2(OiPr)4 (L = bis(triazine)) was synthesized where each octahedral Ti(IV) center is also bound to two isopropoxo groups. The complex rigidity is manifested in a significant deviation from planarity of the aromatic systems, and relatively long Ti-N bonds compared to mononuclear analogous complexes. Increased ligand lability in this complex brings about diminished cytotoxicity toward colon and ovarian cells.

Study Snapshot

Ethylene-bridged bis(hydroxylamino-1,3,5-triazine) compounds show different rotation restrictions, and their rigid dinuclear Ti(IV) complex reduces cytotoxicity towards colon and ovarian cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and conformational analysis of constrained ethylene-bridged bis(hydroxylamino-1,3,5-triazine) compounds as tetradentate ligands; structure of rigid dinuclear Ti(IV) complex.

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References

Citations

Design and Modulation of Selectivity toward Vanadium(V) and Uranium(VI) Ions: Coordination Properties and Affinity of Hydroxylamino-Triazine Siderophores

The synthesized binucleating ligands show high selectivity for vanadium(V) and uranium(VI) ions, offering potential for efficient separation of these metals from solutions.

Cytotoxic homoleptic Ti(iv) compounds of ONO-type ligands: synthesis, structures and anti-cancer activity.

The synthesized Ti(iv) compounds show high hydrolytic stability and show promising anti-cancer activity against ovarian A2780 and colon HT-29 cancer cells.

Crown-linked dipyridylamino-triazine ligands and their spin-crossover iron(II) derivatives: magnetism, photomagnetism and cooperativity.

Complexes 1, 2, and 4 remain in the high-spin state at all temperatures, while complexes 5, 6 and 7 undergo gradual spin transitions with anticooperativity.

Molybdenum(VI) coordination chemistry of the N,N-disubstituted bis(hydroxylamido)-1,3,5-triazine ligand, H2bihyat. Water-assisted activation of the Mo(VI)═O bond and reversible dimerization of cis-[Mo(VI)O2(bihyat)] to [Mo(VI)2O4(bihyat)2(H2O)2].

The study reveals that molybdenum(VI) compounds with ligand H(2)bihyat exhibit high hydrolytic stability in aqueous solution at pH 3-5, offering potential for novel molybdenum(VI) compounds.

Rational Synthesis of a Family of Neutral Monomeric Heteroleptic Titanium Complexes Based on an Octahedral TiO4N2 Motif

This study presents a rational approach for synthesizing a family of neutral monomeric heteroleptic titanium complexes based on an octahedral TiO4N2 motif, with promising properties for various applications.