Li Zhi-yu
2012
Citations
0
Influential Citations
5
Citations
Journal
Fine Chemical Intermediates
Abstract
4-Isothiocyanato-2-(trifluoromethyl)benzonitrile(2) was synthesized from 4-amino-2-(trifluoromethyl)benzonitrile and carbon disulfide.4-Amino-2-fluoro-N-methylbenzamide(5) was synthesized starting from 2-fluoro-1-methyl-4-nitro-benzoic acid via oxidation,amidation and reduction.2-(3-Fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropanoate(6) was produced by Hofmann alkylation of 5.Combination of 2 and 6 in dry DMF produced MDV3100(1) in overall yield of 18%.The structures were confirmed by MS and 1H NMR.