A. Bogdanowicz, H. Foks, K. Gobis
May 1, 2013
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0
Influential Citations
4
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
2-Bromo-4-(pyrrolidin-1-yl)pyridine-3-carbonitrile obtained from 2-(1,3-bis(pyrrolidin-1-yl)allylidene)malononitrile has been used as a substrate for the synthesis of new cyanopyridine derivatives: 2-methoxy, 2-phenoxy, 2-aminoethylthio, and 2-thioxo. 4-(Pyrrolidin-1-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 7 in reaction with suitable alkyl and aminoalkyl halides gave respective sulfides. All synthesized compounds were evaluated for their antimicrobial activity against 26 aerobic and anaerobic bacteria. Determined minimal inhibitory concentration values ranged from 6.2 to 100 µg/mL. Derivatives 1, 3, 4, 6, and 12 were the most active compounds.