K. Mogilaiah, R. Rao, G. Sudhakar
Apr 1, 2001
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0
Influential Citations
2
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Journal
ChemInform
Abstract
Ethyl 1,8-napthyridin-2-one-3-carboxy late 1 on reaction with hydrazine hydrate furnishes 1,8-naphthyridin-2-one-3-carboxylic ac id hydrazide 2, which on treatment with different aromatic aldehydes yields I ,8-naphlhyridin-2-one-3-carboxylic acid arylidenehydrazides 3. Cyclocondensation of 3 with mercaptoacetic ac id in DMF in the presence of anhyd. ZnCI1 affords 2-ary l-3-( I ,8naphthyridin-2-one-3-carbonylamino)-4-thiazolidinones 4. Structure elucidation of the products has been deduced on the basis of elemental analyses, IR , 'H NMR and MS data. Compounds 4 have been sc reened for their antibacteria l activity against both grampositive and gram-negati ve bacteria.