I. Singh, H. Kaur, Sunil Kumar
2010
Citations
0
Influential Citations
3
Citations
Journal
International journal of pharma and bio sciences
Abstract
A series of N-(6-bromo-2-methyl-4-oxoquinazolin-3(4H)-yl)-2-(4-(3-chloro-2-(substitutedphenyl)-4oxoazetidin-1-yl)-5-(pyridin-4-yl)-5-thio)acetamido -1,2,4-triazoles ( 5a-5g) have been prepared by the condensation of 6-bromo-2-methyl-4-oxoquinazolin-3(4H)-yl-2-(4-(substitutedbenzylideneamino)-5-(pyridi n-4yl)-3-thio)acetamido-1,2,4-triazoles ( 4a-4g) with chloroacetyl chloride in presence of trimethy lamine. N-(6bromo-2-methyl-4-oxoquinazolin-3(4H)-yl)-2-(4-(2-(substitutedphenyl)-4-oxothiazolidin-3-yl)-5-(pyridin -4-yl)3-thio)acetamido-1,2,4-triazoles ( 6a-6g) have been synthesized by the reaction of compounds 4a-4g with thioglycolic acid in presence of anhydrous zinc chl oride. All the newly synthesized compounds were screened for their antibacterial activity against S.aureus, E.coli, P.vulgaris, K. pneumoniae. Structures of al l the compounds were established by elemental and spectral (IR, 1 H NMR and Mass) analysis.