Liu Ying-xiang
2007
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Quality indicators
Journal
Journal of Guangdong College of Pharmacy
Abstract
Objective Synthesis of 2-{[(2-Chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid (1) was studied。Method p-Methylaniline and chloroacetic chloride as starting material were subjected by amidation, etherification, Smiles rearrangement, chloroacetylation, cyclization and hydrolysis to afford title compound 1. Result The chemical structure of final product 1 was characterized with elemental analysis, IR, 1H-NMR, 13C-NMR as well as MS data, and the intermediates were confirmed with IR and 1H-NMR. Conclusion The improved drug preparation method is simpler, economical and convenient compared with the reported one, with the overall yield of 66%.