Synthesis and anticancer activity of (RS)-9-(2,3-dihydro-1,4-benzoxaheteroin-2-ylmethyl)-9H-purines.

doi:10.1016/j.ejmech.2011.05.046

Paper

Synthesis and anticancer activity of (RS)-9-(2,3-dihydro-1,4-benzoxaheteroin-2-ylmethyl)-9H-purines.

Published Sep 1, 2011 · A. Conejo-García, M. E. García-Rubiño, J. Marchal

European journal of medicinal chemistry

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43

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Abstract

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In Vitro Study

Study Snapshot

The most active compound, (RS)-2,6-dichloro-9-(2,3-dihydro-1,4-benzoxathiin-2-ylmethyl)-9H-purine, significantly increases apoptosis in human breast cancer cells, with increased phosphorylation of

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and anticancer activity of (RS)-9-(2,3-dihydro-1,4-benzoxaheteroin-2-ylmethyl)-9H-purines.

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