Hai-Ming Zhang, Hong-jian Zhang, Yu-Shun Tian
2017
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
Chinese Journal of Organic Chemistry
Abstract
Four series of derivatives, 6-substituted-1,2,4-triazolo[3,4- a ] phthalazine derivatives and 6-substituted tetrazo-lo[5,1- a ]phthalazine derivatives have been synthesized. The structures of compounds are confirmed by 1 H NMR, 13 C NMR, IR and HRMS. The anticonvulsant effects of the compounds are evaluated with maximal electroshock test by intraperitoneally injected in mice. The experimental results show that N -(4-bromophenyl)tetrazolo[5,1- a ]phthalazin-6-amine ( 7a ) was the most potent compound, with a median effective dose of 5.89 mg•kg - 1 . Its anticonvulsant effect is better than the reference drug, carbamazepine.