Synthesis and Antifungal Activities of N‐Aryl‐4‐phenyl‐3‐(4‐phenoxyphenyl)butanamides

doi:10.1002/(SICI)1521-4184(199910)332:10<333::AID-ARDP333>3.0.CO;2-4

Paper

Synthesis and Antifungal Activities of N‐Aryl‐4‐phenyl‐3‐(4‐phenoxyphenyl)butanamides

Published Oct 1, 1999 · So Ha Lee, In-O Kim, C. Cheong

Archiv der Pharmazie

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Abstract

Various N‐aryl‐4‐phenyl‐3‐(4‐phenoxyphenyl)butanamides (2 and 3) were tested for fungicidal activities against Pyricularia oryzae, Rhizoctonia solani, Botrytis cinerea, Phytophthora infestans, Puccinia recondita, and Erysiphe graminis in vivo. Butanamides (2 and 3a) that have an electron withdrawing group (Cl, F) attached to the meta position of the phenyl ring showed good to excellent activities against Pyricularia oryzae, Puccinia recondita, and Erysiphe graminis in high concentration while those that have a strong electron withdrawing group (CN, NO2) or electron donating group (OCH3, CH3) attached to the meta position did not show good activities against all test fungi at 250 mg L‐1. The antifungal activities of the compounds synthesized were compared with reference compounds such as Tricyclazole, Moncozeb, and Benomyl.

In Vitro Study

Study Snapshot

N-aryl-4-phenyl-3-(4-phenoxyphenyl)butanamides with electron withdrawing groups show good to excellent antifungal activities against Pyricularia oryzae, Puccinia recondita, and Erysiphe graminis, while those

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and Antifungal Activities of N‐Aryl‐4‐phenyl‐3‐(4‐phenoxyphenyl)butanamides

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References

Citations

Structure-activity relationship of some pentacoordinated Tributyltin(IV) complexes derived from sterically hindered Schiff bases of heterocyclic β-diketones

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Copper and palladium co-catalyzed hydroarylation of terminal 1,3-dienes allows for versatile, bio-active compounds with good functional group tolerance.

Nickel-Catalyzed 1,2-Diarylation of Alkenyl Carboxylates: A Gateway to 1,2,3-Trifunctionalized Building Blocks.

Nickel-catalyzed 1,2-diarylation of alkenyl carboxylates leads to improved bioactive molecules with improved yield and step count.

Synthesis and Antifungal Studies of (2E)-N-Benzyl-N′-phenylbut-2-enediamide and (2E)-N,N′-Dibenzylbut-2-enediamide Analogues

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