Synthesis and Antimicrobial Activities of 2-((α- Methylbenzylidene)hydrazino)benzoxazoles.

doi:10.1002/CHIN.199747146

Paper

Synthesis and Antimicrobial Activities of 2-((α- Methylbenzylidene)hydrazino)benzoxazoles.

Published Nov 18, 1997 · S. Ersan, S. Nacak, R. Berkem

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Abstract

New 2-[(alpha-methylbenzylidene)hydrazino]benzoxazole derivatives have been synthesized by reacting ortho or para substituted acetophenones with 2-hydrazinobenzoxazole in ethanol. The structures of the synthesized compounds were confirmed by microanalysis, IR and NMR spectral data. Antimicrobial activities of the compounds were investigated by the microdilution susceptibility test in Mueller-Hinton broth and Sabouraud liquid medium. Test organisms: Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 as Gram (+) bacteria, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa, ATCC 27853 as Gram (-) bacteria, and Candida albicans, Candida stellatoidea, Candida parapsilosis and Candida pseudotropicalis as yeasts. Among the compounds tested 2-[(alpha-methyl-4-chlorobenzylidene)hydrazino]benzoxazole (compounds 4) and 2-[(alpha-methyl-4-nitrobenzylidene)hydrazino]benzoxazole (compound 8) showed the most favorable activity.

Study Snapshot

2-[(alpha-methylbenzylidene)hydrazino]benzoxazole derivatives show promising antimicrobial activity against various bacteria and yeasts.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and Antimicrobial Activities of 2-((α- Methylbenzylidene)hydrazino)benzoxazoles.

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References

Citations

Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes

Complex 1, a copper complex, shows promising anticancer activity against breast, prostate, and colorectal cancer cell lines.

Synthesis of some novel 2-substituted benzoxazoles as anticancer, antifungal, and antimicrobial agents

Novel 2-substituted benzoxazole derivatives show promising anticancer, antifungal, and antibacterial activities, offering potential for new, potent, and less toxic anticancer, antiviral, and antimicrobial agents.

Synthesis and microbiological activity of some N-(2-hydroxy-4-substitutedphenyl)benzamides, phenylacetamides and furamides as the possible metabolites of antimicrobial active benzoxazoles.

Compound II 10 shows better antifungal activity than its cyclic analogue, benzoxazole IV, against Candida albicans.