U. Kulandaivelu, V. Padmini, K. Suneetha
Feb 1, 2011
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Influential Citations
47
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Quality indicators
Journal
Archiv der Pharmazie
Abstract
Thiosemicarbazones of p‐aminobenzoic acid (PABA) were synthesized and tested for their antimicrobial and anticancer activity. Hydroxamate derivatives 4a–4l were found to have better antimicrobial and anticancer activity than their acid counterpart. Compound 4d was found to have good antimicrobial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Vibrio cholerae, and Bacillus subtilis with IC50 value of about 1 µM. Compound 4f showed potent antifungal activity against Candida albicans (IC50 = 1.29 µM) and compound 4h showed potent anticancer activity (IC50 = 0.07 µM).