Synthesis and Antimicrobial Screening of Some Novel 2‐(5‐(4‐(1H‐Benzo[d][1,2,3]triazol‐1‐yl)phenyl)‐4,5‐dihydro‐1H‐pyrazol‐3‐yl)phenols Incorporated by Triazole Moiety

doi:10.1002/JHET.1646

Paper

Synthesis and Antimicrobial Screening of Some Novel 2‐(5‐(4‐(1H‐Benzo[d][1,2,3]triazol‐1‐yl)phenyl)‐4,5‐dihydro‐1H‐pyrazol‐3‐yl)phenols Incorporated by Triazole Moiety

Published Mar 1, 2014 · M. Shaikh, G. Jadhav, R. Kale

Journal of Heterocyclic Chemistry

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Abstract

A novel series of 2-(5-(4-(1H-benzo[d][1,2,3]triazol-1-yl)phenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenols derivative has been synthesized from (E)-3-(4-(1H-benzo[d][1,2,3]triazol-1-yl)phenyl)-1-(2-hydroxyphenyl)prop-2-en-1-ones in ethanol and hydrazine hydrate under reflux condition. The synthesized compounds were screened for antibacterial activity against Gram-positive bacteria viz Staphylococcus aureus and Bacillus subtilis and Gram-negative bacteria viz Escherichia coli and Salmonella typhi, respectively. Some of the tested compounds showed significant antimicrobial activity. IR, 1H NMR, mass spectral data, and elemental analysis elucidated the structures of all the newly synthesized compounds.

Study Snapshot

Novel 2-(5-(4-(1H-benzo[d][1,2,3]triazol-1-yl)phenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenols show significant antimicrobial activity against Gram-positive and Gram-negative bacteria.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and Antimicrobial Screening of Some Novel 2‐(5‐(4‐(1H‐Benzo[d][1,2,3]triazol‐1‐yl)phenyl)‐4,5‐dihydro‐1H‐pyrazol‐3‐yl)phenols Incorporated by Triazole Moiety

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Citations

Environmentally Benign Ultrasound Promoted Synthesis of Some Important Pyrazoline Derivatives as Antibacterial and Antifungal Agents

Ultrasound-promoted synthesis of pyrazoline derivatives (4a-f) yields environmentally benign compounds with promising antibacterial and antifungal properties.

Synthesis, molecular docking and biological evaluation of some novel tetrazolo[1,5-a]quinoline incorporated pyrazoline and isoxazoline derivatives

Novel pyrazolines and isoxazolines synthesized under ultrasound irradiation show significant antimicrobial and antioxidant activity, with potential drug-like properties.

Synthesis and Screening of Biological Activities of Some Important Pyrazoline Derivatives

Synthetic pyrazolines derivatives (4a-f) show reasonable to good antimicrobial activity against various bacteria and fungi strains, with potential applications in pharmaceuticals and cosmetics.