SYNTHESIS AND ANTIMYCOTIC ACTIVITY OF NEW 2-CHLORO-3-(2-NITRO)ETHYL- AND (2-NITRO)VlNYLQUINOLINES

doi:10.1515/HC.1996.2.1.63

Paper

SYNTHESIS AND ANTIMYCOTIC ACTIVITY OF NEW 2-CHLORO-3-(2-NITRO)ETHYL- AND (2-NITRO)VlNYLQUINOLINES

Published 1996 · Z. Cziáky, F. Kóródi, L. Frank

Heterocyclic Communications

Q3 SJR score

2

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0

Influential Citations

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Abstract

2-Chloro-3-(2-nitro)ethyland (2-nitro)vinylquinolines have been synthesized and tested in vitro for their antimycotic activity against Aspergillus fumigatus, Trichophyton mentagrophytes, Microsporum gypseum, Epidermophyton floccosum and Candida albicans. Several compounds exhibited strong inhibition to microorganisms.

Study Snapshot

New 2-chloro-3-(2-nitro)ethyl and (2-nitro)vinylquinolines show strong antimycotic activity against various fungal pathogens.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

SYNTHESIS AND ANTIMYCOTIC ACTIVITY OF NEW 2-CHLORO-3-(2-NITRO)ETHYL- AND (2-NITRO)VlNYLQUINOLINES

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References

Structure-activity relationships in a series of new antifungal nitroalcohol derivatives

Antifungal activity of new nitroalcohol derivatives is mainly determined by the presence or absence of aromatic rings, double bonds, and acyloxy groups, with the double bond being the most important factor.

Synthesis and antifungal activity of new nitro-alcohol derivatives

New nitro-alcohol derivatives show high antifungal activity against Helminthosporium sativum, with interesting relationships between structure and antifungal action.

Diastereoselective Synthesis of Nitroaldol Derivatives

Diastereoselective synthesis of nitroaldol derivatives allows for the preparation of threo-Nitroaldols and their O-silylated derivatives without loss of configurational purity.

Citations

Synthesis, Antimicrobial, DFT, and In Silico Pharmacokinetic Profiling of Nitroaldol Quinoline Derivatives: A Comprehensive Exploration for Designing Potential Oral Antibacterial Agents Targeting DNA-Gyrase

Nitroaldol quinoline derivatives show potential as oral antibacterial agents targeting DNA-gyrase, with promising water solubility, bioavailability, and minimal inhibitory effects on specific enzymes.