L. Savegnago, A. Vieira, Natália Seus
Jan 2, 2013
Citations
1
Influential Citations
77
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Quality indicators
Journal
Tetrahedron Letters
Abstract
Abstract Herein we describe our results on the synthesis and antioxidant properties of 4-arylchalcogenyl-7-chloroquinolines. This new class of compounds has been synthesized in high yields by the reaction of 4,7-dichloroquinoline with diaryl dichalcogenides using KOH as base, DMSO as solvent at 100 °C under air atmosphere and tolerates a range of substituents in the arylchalcogenyl moiety. The obtained compounds 3a and 3j were screened for in vitro antioxidant activity and the results demonstrated that compound 3j presented a potent antioxidant effect when compared to compound 3a .