H. Liszkiewicz
2002
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Polish Journal of Chemistry
Abstract
Reaction of 2,3-diaminopyridine with equimolar amount of benzoylacetone in ethanol solution in the presence of catalytic amounts of acetic acid allowed to obtain 3-(2-amino-pyridin-3-ylamino)-1-phenyl-2-buten-1-one (4) instead of 2-methyl-4-phenyl-3H-pyrido[2,3-b][1,5]diazepine (3) reported in the literature. Treatment of compound 4 with appropriate aromatic aldehydes: benzaldehyde and substituted benzaldehyde (4-methoxy-, 3,4-dimethoxy-, 3,4,5-trimethoxy-, 3-metyl-4-methoxy-, 3-hydroxy-, 4-diethyloamino-) in methanol solution in the presence of equimolar amount of potassium hydroxide gave 1-phenyl-2-(aryl-1,3,4,5-tetrahydropyrido[2,3-b][1,4]-diazepin-2-ylidene)-ethanones (7-13). Structures of compounds 4 and 7 were determined on a single crystal. Compounds 4 and 7-13 were examined for their antiproliferative activity in vitro against the cells of 7 human cancer cell lines, using SRB or MTT technique. Two out of all tested compounds revealed cytotoxic activity in vitro.