Synthesis, Antitubercular Activity, and Molecular Docking Studies of Novel 2-(4-Chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamides

doi:10.1134/S1070363219040327

Paper

Synthesis, Antitubercular Activity, and Molecular Docking Studies of Novel 2-(4-Chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamides

Published Apr 1, 2019 · B. Srinu, R. Parameshwar, G. Kali Charan

Russian Journal of General Chemistry

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Abstract

A novel series of 2-(4-chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamide derivatives are synthesized and their structures are confirmed by 1H and 13C NMR, and MS spectral data. The compounds are screened for their antitubercular activity, and those with aryl moiety 7o, 7q, and 7r demonstrate potent activity against Mycobacterium tuberculosis. Docking studies suggest a mode of interaction of the products with the binding site of enoyl-CoA hydratase demonstrating that the target compounds were potential anti-TB agents.

In Vitro Study

Study Snapshot

Novel 2-(4-chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamide derivatives show potent antitubercular activity against Mycobacterium tuberculosis, with potential as anti-TB agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis, Antitubercular Activity, and Molecular Docking Studies of Novel 2-(4-Chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamides

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References

Design, Synthesis and Biological Evaluation of Novel Urea and Thiourea Bearing thieno[3,2-d]-pyrimidines as PI3 Kinase Inhibitors.

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Novel indole analogs synthesized using microwave-assisted, solvent-free methods show promising antitubercular and antimicrobial properties, with compounds containing halogens being most potent.

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Citations

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