Wei Bang-guo
2008
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Journal
Journal of Northwest Normal University
Abstract
A convenient and practical synthetic method for antitumor compound 2-methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridine-3-yloxy)phenylamino]quinazolin-6-yl}-E-allyl)acetamide(CP724,714) is accomplished with high overall yields(28%) from 6-methylpyridine-3-ol and high regioselectivity of key step(96:4) based on the Heck coupling reaction which is catalyzed by Pd(OAc)2.Furthermore,the purity of this oncology candidate is 99.8% based on HPLC value.