T. Itoh, Jun-ichi Chika, Y. Takagi
Oct 1, 1993
Citations
0
Influential Citations
44
Citations
Journal
Journal of Organic Chemistry
Abstract
Efficient preparation of optically pure 4-hydroxyalkanenitriles, 1a-f, was achieved via an enzymatic reaction using lipase PS (Pseudomonas sp.). Optically pure (R)-4-hydroxy-3-[[3,4-(methylenedioxy)phenyl]methyl]butanenitrile (1a) was applied to the enantioselective synthesis of three types of antitumor lignans, (-)-hinokinin, (-)-isodeoxypodophyllotoxin, and (+)-isostegane