Paper
[Synthesis and antiulcer activity of 2-amino-8H-indeno[1,2-d]thiazole derivatives].
Published Jul 1, 1994 ยท H. Inoue, K. Ikesue, T. Mizoguchi
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
0
Citations
0
Influential Citations
Abstract
A series of 8H-indeno[1,2-d]thiazoles containing various N-substituted amino groups at the 2 position were synthesized by the reaction of 2-bromo-indanones and N-substituted thioureas. Their anti-ulcerous activity was evaluated. Alkylamino derivatives have a more potent inhibitory behavior on ethanol-induced gastric ulcers compared with arylamino derivatives. We also studied the effect of various substituents on the both benzene and pyridine ring of 2-pyridylamino derivatives on ethanol-induced gastric ulcers. However no clear effects were observed. Among 3-morpholinopropylamino derivatives, 5-isopropyl- (21) and 7-chloro-2-(3-morpholinopropyl)amino-8H-indeno[1,2-d]thiazole (25) showed a considerably stronger inhibitory behavior on hydrochloric acid-induced gastric ulcers than cetraxate hydrochloride. Furthermore, 3-morpholinopropylamino derivatives have potent inhibitory effects on gastric acid secretion in pylorus ligated rats.
Non-RCT
Animal StudyAlkylamino derivatives of 8H-indeno[1,2-d]thiazole show more potent inhibitory behavior on ethanol-induced gastric ulcers than arylamino derivatives, while 3-morpholinopropylamino derivatives show stronger inhibitory behavior on hydrochloric acid
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...