Synthesis and Biological Activity of N-(Indolyl)trifluoroacetamides Based on Substituted 6-Aminoindoles

doi:10.3103/S0027131420060152

Paper

Synthesis and Biological Activity of N-(Indolyl)trifluoroacetamides Based on Substituted 6-Aminoindoles

Published Nov 1, 2020 · I. S. Stepanenko, S. Yamashkin, M. Yurovskaya

Moscow University Chemistry Bulletin

Q4 SJR score

1

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

The acylation of substituted 6-aminoindoles with ethyl trifluoroacetate is studied during the synthesis of new N-(indol-6-yl)trifluoroacetamides. The features of the reaction depending on the nature of the ortho-substituent relative to the amino group in the benzene ring of the indole molecule are found. The obtained compounds being in an exclusively amide tautomeric form are screened for antimicrobial activity against the S. aureus 6538, S. aureus 43300 (МRSА), E. coli 25 922, P. aeruginosa 27 853, and S. pyogenes 19 615 microorganism strains. The revealed antimicrobial activity of the studied compounds exceeds the activity of the reference drug dioxydine.

Study Snapshot

N-(indolyl)trifluoroacetamides show promising antimicrobial activity against various bacteria, surpassing the reference drug dioxydine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Synthesis and Biological Activity of N-(Indolyl)trifluoroacetamides Based on Substituted 6-Aminoindoles

Sign up to use Study Snapshot

References

Synthesis and Antimicrobial Activity of N-(Indolyl)trifluoroacetamides

N-(Indolyl)trifluoroacetamides show antimicrobial activity comparable to dioksidin, making them a promising new antimicrobial agent.

Ab Initio Calculation of Vibrational Absorption and Circular Dichroism Spectra Using Density Functional Force Fields

The B3LYP force field provides excellent agreement with experiment for mid-IR spectra of 4-methyl-2-oxetanone, while MP2 and SCF force fields yield slightly worse results.

Self—Consistent Molecular Orbital Methods. XII. Further Extensions of Gaussian—Type Basis Sets for Use in Molecular Orbital Studies of Organic Molecules

The extended basis sets (5-31G and 6-31G) significantly lower calculated total energies in organic molecular orbital studies, while maintaining relative energies and equilibrium geometries.

The ORCA program system

ORCA is a general-purpose quantum chemistry program package that features modern electronic structure methods and is designed for generality, extendibility, efficiency, and user friendliness.

Citations

Development of novel effective agents from 1H-indolylammonium trifluoroacetates effective against conditionally pathogenic microorganisms

The compounds 5-8 show pronounced antibacterial activity against conditionally pathogenic microorganisms, potentially serving as water-soluble synthetic antimicrobial agents to combat antibiotic resistance.

Synthesis and Biological Activity of N-(Indolyl)trifluoroacetamides Based on Substituted 6-Aminoindoles

Sign up to use Study Snapshot

References

Synthesis and Antimicrobial Activity of N-(Indolyl)trifluoroacetamides

N-(Indolyl)trifluoroacetamides show antimicrobial activity comparable to dioksidin, making them a promising new antimicrobial agent.

Ab Initio Calculation of Vibrational Absorption and Circular Dichroism Spectra Using Density Functional Force Fields

The B3LYP force field provides excellent agreement with experiment for mid-IR spectra of 4-methyl-2-oxetanone, while MP2 and SCF force fields yield slightly worse results.

Self—Consistent Molecular Orbital Methods. XII. Further Extensions of Gaussian—Type Basis Sets for Use in Molecular Orbital Studies of Organic Molecules

The extended basis sets (5-31G and 6-31G) significantly lower calculated total energies in organic molecular orbital studies, while maintaining relative energies and equilibrium geometries.

The ORCA program system

ORCA is a general-purpose quantum chemistry program package that features modern electronic structure methods and is designed for generality, extendibility, efficiency, and user friendliness.

Citations

﻿Development of novel effective agents from 1H-indolylammonium trifluoroacetates effective against conditionally pathogenic microorganisms

The compounds 5-8 show pronounced antibacterial activity against conditionally pathogenic microorganisms, potentially serving as water-soluble synthetic antimicrobial agents to combat antibiotic resistance.

Development of novel effective agents from 1H-indolylammonium trifluoroacetates effective against conditionally pathogenic microorganisms