G. Kabalka, Min-Liang Yao
Dec 1, 2003
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Influential Citations
13
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Journal
Synthesis
Abstract
A novel boronated aminocyclobutanecarboxylic acid was synthesized for potential use in neutron capture therapy. The synthesis involves the preparation of tosylate 5, which was then converted to an amino acid using Bucherer-Strecker methodology. The molecule was modeled after the unnatural amino acid, 1-aminocyclobutane-1-carboxylic acid, which has shown high uptake in brain tumors.