Synthesis, Characterisation and Antifungal Activities of[4-Methylphenylsulphonamido]-N-(Pyridin-2 Yl) Acetamide Derivatives

doi:10.4172/2161-0444.1000160

Paper

Synthesis, Characterisation and Antifungal Activities of[4-Methylphenylsulphonamido]-N-(Pyridin-2 Yl) Acetamide Derivatives

Published Jan 26, 2014 · D. I. Ugwu, U. Okoro

Medicinal Chemistry

Q3 SJR score

6

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

In the present study, a series of N-pyridin-2-yl substituted [4-methylphenylsulphonamido] acetamides have been synthesized. The reaction of 4-methylphenyl sulphonyl chloride 1 with various amino acids 2a-e in basic medium yielded [4-methylphenylsulphonamido] alkanoic acids 3a-e which on chlorination with thionyl chloride gave the acid chloride derivatives of [4-methylphenylsulphonamido] alkanoic acid in situ. The acid chloride derivatives on condensation with 2-aminopyridine 4, gave the corresponding acetamides 5a-e in good to excellent yield. The compounds were characterized by FTIR, 1H-NMR and 13C-NMR and screened for antifungal activities against Candida albican and Aspergillus niger. The results revealed that the compounds had betterantifungal activity than fluconazole the reference drug. Compound 5d was most active against Candida albicans with MIC of 0.224 mg/mL and compound 2b most active against Aspergillus niger with MIC of 0.190 mg/mL.

Study Snapshot

The synthesized N-pyridin-2-yl substituted [4-methylphenylsulphonamido]-N-(pyridin-2-yl) acetamide derivatives show better antifungal activity than fluconazole, with compound 5d being most active against Candida alb

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Synthesis, Characterisation and Antifungal Activities of[4-Methylphenylsulphonamido]-N-(Pyridin-2 Yl) Acetamide Derivatives

Sign up to use Study Snapshot

References

Synthesis and antibacterial activity of sulfonamide derivatives at C-8 alkyl chain of anacardic acid mixture isolated from a natural product cashew nut shell liquid (CNSL)

Novel sulfonamide derivatives from cashew nut shell liquid show higher antibacterial activity compared to standard ampicillin, offering potential for new antibiotic treatments.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF VARIOUS N-SUBSTITUTED DERIVATIVES OF SULFONAMIDES

N-substituted sulfonamides synthesized in this study show good inhibitory potential against lipoxygenase, with N-butyl-N-(4, 5-dibromo-2-methoxyphenyl)benzene sulfonamide (6d

Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes

New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives show potential as new antimalarial lead compounds, with trifluoromethyl-substituted derivatives being the best lead compounds for further development

Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors.

N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides show higher aldose reductase inhibitory activity and antioxidant potential, potentially aiding in the design of pharmacotherapeutic agents for diabetes mellitus long-term complications.

Antileukemic activity of sulfonamide conjugates of arabinosylcytosine.

Slow liberation of araC from both conjugates extends their therapeutic action and protects them from inactivation, potentially benefiting leukemia treatment.

Zonisamide: chemistry, mechanism of action, and pharmacokinetics

Zonisamide is a synthetic anticonvulsant with a dual mechanism of action, potentially effective in patients resistant to other antiepileptic drugs.

Effects of avitriptan, a new 5-HT1B/1D receptor agonist, in experimental models predictive of antimigraine activity and coronary side-effect potential

Avitriptan may be effective in treating migraine headaches but may exhibit sumatriptan-like effects on coronary arteries.

Antimicrobial potentials of Diospyros mespiliformis (Ebenaceae).

Diospyros mespiliformis root extract shows the highest antimicrobial activity against various bacteria and fungi, with potential therapeutic applications.

Citations

New antibacterial, antifungal and antioxidant agents bearing sulfonamide

New compounds with sulfonamides show improved antibacterial, antifungal, and antioxidant properties compared to ciprofloxacin and ketoconazole, with compound 20 being a lead agent.

Diazabenzo[a]phenoxazone sulphonamides: synthesis, in-silico and in-vitro antimicrobial studies

Most of the synthesized compounds showed comparable antimicrobial activities to colymycin, suggesting potential as new antibacterial and antifungal drugs.

Synthesis, Characterization and Antibacterial Activity of 2-Phenylsulphonamide Derivatives of Some Amino Acids

2-Phenylsulphonamide derivatives of amino acids show effective antibacterial properties, but some may not be more active than ciprofloxacin.

2-Imino-(3,4-dimethoxybenzyl) ethanesulfonic acid Schiff base anchored silver nanocomplex mediated by sugarcane juice and their antibacterial activities

Silver nanocomplexes anchored with 2-imino-(3,4-dimethoxybenzyl)ethane sulphonic acid show potential antibacterial activity, inhibiting the growth of some bacterial strains.

Synthesis of N-aryl substituted p-toluenesulphonamides via nickel catalyzed amidation reaction and their antibacterial, antifungal and antioxidant activities evaluation.

N-aryl substituted p-toluene sulphonamides show promising antibacterial, antifungal, and antioxidant activities, with some showing higher activity than standard treatments.